The information within this section of the website is intended for UK Healthcare Professionals. UK Practice Managers should follow the relevant links.

The pick of the bunch in endometriosis

Prostap DCS at a glance

Prostap DCS (leuprorelin acetate):

  • Has treated over 24 million patients globally since 1996, across all indications1
  • Benefits from over 25 years of experience of leuprorelin in gynaecological conditions
  • Has been shown to effectively control the symptoms of endometriosis, particularly pain2
  • Has a well-established tolerability profile: majority of adverse events are related to gonadal suppression; the most common adverse events are hot flushes, mood swings including depression (occasionally severe) and vaginal dryness3,4*
  • Includes a device that is easy to use which is designed with patient and user experience in mind3,4
  • Helps protect HCPs from needle stick injuries. Prostap DCS is fitted with a safety device that complies with the latest EU sharps directive and UK legislation3-6

                *For a full list of adverse events, please refer to the Prostap DCS summary of product characteristics.3,4

About Prostap DCS3,4

  • Dual Chamber Syringe (DCS) system delivering leuprorelin3,4

Therapeutic indications3,4

Endometriosis

  • Management of endometriosis, including pain relief and reduction of endometriotic lesions
  • Endometrial preparation prior to intrauterine surgical procedures including endometrial ablation or resection (Prostap SR DCS only)
  • Preoperative management of uterine fibroids to reduce their size and associated bleeding (Prostap SR DCS only)

Breast cancer

  • Treatment in pre- and perimenopausal women with advanced breast cancer suitable for hormonal manipulation
  • Adjuvant treatment in combination with tamoxifen or an aromatase inhibitor, of endocrine responsive early stage breast cancer in pre- and perimenopausal women at higher risk of disease recurrence (young age, high grade tumour, lymph node involvement)

Note: In women who have received chemotherapy, premenopausal status must be confirmed after completion of chemotherapy.

Preservation of ovarian function

  • Use in pre-menopausal women with neoplastic disease undergoing chemotherapy treatment that can cause premature ovarian insufficiency (Prostap SR DCS only)

NOTE: Treatment with a GnRH analogue should only be proposed after careful risk/benefit evaluation in each patient. Not a replacement for standard fertility-preservation methods.

Prostate cancer

  • Metastatic prostate cancer
  • Locally advanced prostate cancer, as an alternative to surgical castration
  • As an adjuvant treatment to radiotherapy in patients with high risk localised or locally advanced prostate cancer
  • As an adjuvant treatment to radical prostatectomy in patients with locally advanced prostate cancer at high risk of disease progression
  • As neo-adjuvant treatment prior to radiotherapy in patients with high-risk localised or locally advanced prostate cancer

Central precocious puberty

  • Central precocious puberty in girls under 9 years of age and boys under 10 years of age

Administration overview3,4

Intramuscular (IM) or subcutaneous (SC) administration available, depending on indication and dose

 

Dosage form

Released from micro particles that are 20µm in diameter7 abriefproductoverview-figure13

Needle size

Fine gauge needle

Image not to scale

Dosing – Prostap SR DCS3

Dosing – Prostap 3 DCS4

Contact

If you are a healthcare professional and have a clinical query about Prostap DCS, please call Medical Information on:

01628 537 900

If you would like to find out more about how Prostap DCS can help your practice save money, or to order, please call CLARITYpharma on:

0845 080 5190

If you are a healthcare professional and would like to be contacted about Prostap DCS, please enter your details in the short form below

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Takeda UK Ltd will NOT share any of your details with any other parties. If at any time you wish to unsubscribe from receiving information about Prostap DCS, please call Takeda UK Ltd on 01628 537 900.

References

  1. Takeda UK Ltd. Data on file, DF120604(2).
  2. Crosignani PG et al. Hum Reprod 1996;11(12):2732-5.
  3. Prostap SR DCS. Summary of Product Characteristics.
  4. Prostap 3 DCS. Summary of Product Characteristics.
  5. Health and Safety Executive. Health and Safety (Sharp Instruments in Healthcare) Regulations 2013. Available at: hse.gov.uk/pubns/hsis7.pdf (last accessed July 2019).
  6. European Agency for Safety and Health at Work. Directive 2010/32/EU – prevention from sharp injuries in the hospital and healthcare sector. Available at: https://osha.europa.eu/en/legislation/directives/council-directive-2010-32-eu-prevention-from-sharp-injuries-in-the-hospital-and-healthcare-sector (last accessed July 2019).
  7. Ogawa Y et al. J Pharm 1989;41(7):439-44.
  8. Abouelfadel Z & Crawford D. Therapeut Clin Risk Manag 2008;4(2):513-26.
  9. The Leuprolide Study Group. N Eng J Med 1984;311(20):1281-6.
  10. Friedman AJ et al. Fertil Steril 1987;48(4):560-4.
  11. PharmaTimes online. Takeda launches new presentation of Prostap, 2011. Available at: http://www.pharmatimes.com/news/takeda_launches_new_presentation_of_prostap_980760 (last accessed July 2019).
  12. National Institute for Health and Care Excellence (2019) Prostate cancer, diagnosis and management. NICE  Guideline (NG131).
  13. Zoladex 3.6mg. Summary of Product Characteristics. Available via: http://www.medicines.org.uk/
  14. Decapeptyl SR 3mg. Summary of Product Characteristics. Available via: http://www.medicines.org.uk/
  15. Decapeptyl SR 11.25mg. Summary of Product Characteristics. Available via: http://www.medicines.org.uk/

This part of the Prostap® DCS (leuprorelin acetate) online resource is specifically for Practice Managers. If you are not a Practice Manager, please select the appropriate area of this website from the welcome page.

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This part of the Prostap® DCS (leuprorelin acetate) online resource is specifically for patients who have been prescribed Prostap DCS.

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